4.4 Article

The glycosyltransferase gene encoding the enzyme catalyzing the first step of mycothiol biosynthesis (mshA)

期刊

JOURNAL OF BACTERIOLOGY
卷 185, 期 11, 页码 3476-3479

出版社

AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.185.11.3476-3479.2003

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  1. FIC NIH HHS [TW00976] Funding Source: Medline
  2. NIAID NIH HHS [R01 AI049174, R21 AI049174, AI49174] Funding Source: Medline

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Mycothiol is the major thiol present in most actinomycetes and is produced from the pseudodisaccharide 1D-myo-inosityl 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins). A transposon mutant of Mycobacterium smegmatis shown to be GlcNAc-Ins and mycothiol deficient was sequenced to identify a putative glycosyltransferase gene designated mshA. The ortholog in Mycobacterium tuberculosis, Rv0486, was used to complement the mutant phenotype.

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