期刊
DRUG DISCOVERY TODAY
卷 8, 期 11, 页码 494-502出版社
ELSEVIER SCI LTD
DOI: 10.1016/S1359-6446(03)02707-7
关键词
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资金
- NIDDK NIH HHS [DK 56631] Funding Source: Medline
Membrane trafficking comprises the directed transport of vesicle and/or organelle cargos to specific locations throughout the cell, and is primarily driven by molecular motors tracking along microtubules and microfilaments. The mechanisms by which specific motor complexes attach to their respective vesicular cargo is of great interest, and is only now starting to be unraveled. The proteins identified as links between the molecular motors and the vesicular cargo are viable drug targets and represent opportunities to regulate small groups of related proteins or even single proteins, such as receptors and transporters, at the cytosolic trafficking level. Ultimately, continued development in this area will lead to greater success in directing endocytosed drugs to the desired intracellular targets, such as the cell nucleus or the basolateral membrane.
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