期刊
EUROPEAN JOURNAL OF HAEMATOLOGY
卷 70, 期 6, 页码 392-397出版社
BLACKWELL MUNKSGAARD
DOI: 10.1034/j.1600-0609.2003.00071.x
关键词
deferiprone; desferrioxamine; chelation; thalassemia; cardiac; iron overload; cardiac function; magnetic resonance imaging; left ventricular ejection fraction
类别
We conducted a prospective 3-yr clinical study comparing deferiprone (L1) with desferrioxamine (DFX). The therapeutic efficacy and potential side-effects on cardiac and/or hepatic systems of thalassemia patients were assessed by left ventricular ejection fraction, T2-weighted magnetic resonance imaging, and biochemical parameters. In both groups, levels of serum ferritin decreased significantly, and the hepatic function improved notably. Besides decrement of iron, no marked pathohistological changes were observed in the liver biopsies. These results indicated that for patients who failed to respond to DFX treatment, the use of L1 to remove excess iron deposition is recommended.
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