期刊
PROTEOMICS
卷 3, 期 6, 页码 847-850出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/pmic.200300362
关键词
in-source collision-induced dissociation; parallel peptide tandem mass spectrometry; peptide mixtures
Parallel collision-induced dissociation (CID) of peptides rather than serial, as is customary, results in loss of the obvious parent-fragment ion lineage available from CID on a single ion. We report proof-of-principle results suggesting the feasibility of parallel peptide CID, referred to here as shotgun CID, for protein identification when using the measured mass accuracies available from a time of flight mass analyzer and currently available search routines such as SEQUEST Additionally, we report that parent-fragment ion lineage may be reconstructed from information encoded in the chromatographic single ion current traces of peptides.
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