期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 27, 期 4, 页码 401-411出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0149-7634(03)00070-8
关键词
acetylcholine; mouse; Rett syndrome; Down syndrome; learning and memory; sex differences
资金
- NINDS NIH HHS [5 R44 NS34591-03] Funding Source: Medline
This review seeks to address, though perhaps not answer fully, four important questions about the cholinergic basal forebrain (BF) system in developing mammals. First, what role does the cholinergic basal forebrain system play in the development of cognitive functions? Second, does the cholinergic BF system play a fundamentally similar role in development vs. adulthood? Third, does sexual dimorphism of the developing cholinergic BF system influence cognition differently in the two sexes? Finally, what role does the developing cholinergic BF system play in developmental disorders such as Down syndrome and Rett syndrome? Examples from the literature, primarily studies in mice and rats, are given in an attempt to answer these important questions. (C) 2003 Elsevier Ltd. All rights reserved.
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