期刊
ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA
卷 53, 期 2, 页码 293-300出版社
SBEM-SOC BRASIL ENDOCRINOLOGIA & METABOLOGIA
DOI: 10.1590/S0004-27302009000200022
关键词
Obesity; adiponectin; insulin resistance; weight loss; gastric bypass; HDL-cholesterol; glucose clamp technique
资金
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (Fapesp)
- Fundacao de Apoio ao Ensino e Pesquisa (FAEP-Unicamp)
Objective: To assess the relationship between adiponectin and metabolic parameters in severely obese women during surgical-induced weight loss. Methods: Nineteen lean (CT - BMI:21.2 +/- 0.3 kg. m(2)), 14 overweight/class II obese (OB/OW - BMI: 29.7 +/- 0.7 kg/m(2)) and 8 morbidly obese (OBIII - BMI: 56.4 +/- 3.6 kg/m(2)) were evaluated by hyperinsulinemic-euglycemic clamp, adiponectin, and lipids. OBIII were evaluated at 5(th) and 16(th) month post-operatively. Results: Compared to lean, obese groups had lower adiponectin (OB/OW: 9.4 +/- 0.9, OBIII: 7.1 +/- 1.3 versus 12.2 +/- 0.9 ng/dL; p < 0.01), lower HDL-cholesterol (OB/OW:1.05 +/- 0.05, OBIII: 0.88 +/- 0.04 versus 1.22 +/- 0.07 mmol/L; p < 0.01) and insulin resistance-IR (glucose uptake M-value - OB/OW: 43.6 +/- 2.7 OBIII: 32.4 +/- 3.2 versus 20.0 +/- 1.8 umol/kgFFM.min; p < 0.001). Considering all subjects, adiponectin levels were inversely correlated to BMI and waist circumference, and directly to M-value and HDL-cholesterol (p < 0.01). During weight loss, improvements in IR (study III: 36.1 +/- 3.9 umol/kg/FFM.min, p < 0.0001), adiponectin (11.8 +/- 1.4 ng/dL, p = 0.006) and HDL-cholesterol were observed (1.10 +/- 0.04 mmol/L, p = 0.007). Moreover, HDL-cholesterol improvement was significantly and independently related to variations of adiponectin and BMI (r(2) = 0.86; p < 0.0002). Conclusions: The improvements of IR and adiponectin were related to surgical-induced weight loss suggesting an important role of adiponectin in HDL-cholesterol regulation. Arq Bras Endocrinol Metab. 2009:53(2):293-300.
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