期刊
INSECT MOLECULAR BIOLOGY
卷 12, 期 3, 页码 225-232出版社
BLACKWELL PUBLISHING LTD
DOI: 10.1046/j.1365-2583.2003.00405.x
关键词
protein kinase B (PKB); insect; ecdysteroids; oogenesis; ovary
资金
- NIAID NIH HHS [AI33108, R01 AI033108] Funding Source: Medline
A key component of the insulin-signalling pathway, the protein kinase Akt, was identified and cloned as a cDNA from ovaries of the mosquito Aedes aegypti . An ortholog gene was found in the Anopheles gambiae genome database, and like other Akts, both mosquito Akts possess pleckstrin homology domains for membrane binding and a serine/threonine kinase domain. When Ae. aegypti ovaries were treated with bovine insulin in vitro , a putative Akt was threonine-phosphorylated, as expected for Akts. AaegAKT was only expressed in embryos for the first 6 h after oviposition and in ovaries before and during a gonotrophic cycle.
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