期刊
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
卷 17, 期 3, 页码 441-458出版社
ELSEVIER SCI LTD
DOI: 10.1016/S1521-6934(03)00008-7
关键词
pre-eclampsia; thrombophilia; pregnancy; thrombosis; factor V Leiden; APCR; prothrombin gene mutation; hyperhomocysteinaemia; methylenetetrahydrofolate reductase; protein S; protein C; antithrombin; low molecular weight heparin (LMWH); aspirin; folate
Pre-eclampsia is a major cause of perinatal and maternal morbidity and mortality worldwide. Although knowledge of the precise aetiology remains uncertain a number of risk factors have been described. Thrombophilias have been associated with pre-eclampsia in a number of studies and it is biologically plausible that they may contribute to the uteroplacental thrombosis that is frequently seen in pre-eclampsia. If this association is confirmed, there is the potential to investigate preventive treatments, including low-molecular-weight heparins, aspirin and folate.
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