期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 13, 期 3, 页码 309-316出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-440X(03)00066-6
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Intrinsic events during RNA folding include conformational search and metal ion binding. Several experimentally testable models have been proposed to explain how large ribozymes accomplish folding. Future challenges include the validation of these models, and the correlation of experimental results and theoretical simulations.
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