Anti-inflammatory activity of 3-benzoyl-1-methyl-4-phenyl-4-piperidinol hydrochloride

In our study. the effects of the compound 3-benzoyl-1-methyl-4-phenyl-4-piperidinol hydrochloride (C1) and also an anti-inflammatory drug, indomethacin, tested by carrageenan-induced paw edema and cotton pellet granuloma tests, for their effects on acute and chronic phases If inflammation. respectively. Their effects on vascular permeability were also tested by hyaluronidase-induced capillary permeability. C1 decreased the carrageenan-induced paw edema 61.98, 80.84, and 90.32% at 50, 100, and 200 mg kg(-1) doses, respectively, while this decrease was 89.93% by indomethacin at 20 mg kg(-1) dose. Antiproliferative effects of C1 at 100 mg kg(-1) and indomethacinin at 20 mg kg(-1) doses were 46.1 and 43.1%. respectively, in cotton pellet test. C1 and indomethacin both significantly inhibited the hyaluronidase-induced increase in capillary permeability. (C) 2003 Elsevier Science Ltd. All rights reserved.