期刊
NEUROLOGICAL RESEARCH
卷 25, 期 4, 页码 351-356出版社
FOREFRONT PUBL GROUP
DOI: 10.1179/016164103101201670
关键词
positron emission tomography; progressive dementia; amyotrophic lateral sclerosis; motor neuron disease; cerebral oxygen metabolism; cerebral blood flow
We examined regional cerebral blood flow (rCBF) and oxygen metabolism (rCMRO(2)) in 70 patients with progressive dementia and amyotrophic lateral sclerosis (DALS), in 21 patients with classical amyotrophic lateral sclerosis without dementia (ALS), and in 17 controls. The mean rCBF and rCMRO(2), especially in the anterior cerebral hemispheres, decreased significantly in patients with DALS. Patients with only ALS showed very mild changes in rCBF and rCMRO(2) which were not significant except for the reductions in the sensorimotor area. Some rCBF and rCMRO(2) values in ALS showed a significant correlation with some neurological signs indicating upper motor neuron involvement. These data suggest that hypoperfusion and oxygen hypometabolism in the anterior cerebral hemispheres have an etiological relationship with the deterioration of intellect in patients with progressive dementia and ALS. The metabolic and perfusional changes in the cerebral cortex of ALS patients are likely to depend on upper motor neuron involvement, but they are not confined to the neurons of the corticospinal tract.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据