期刊
MOLECULAR AND CELLULAR BIOLOGY
卷 23, 期 11, 页码 3774-3787出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/MCB.23.11.3774-3787.2003
关键词
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资金
- NCI NIH HHS [P01 CA076259, P30 CA056036, 5P30CA56036, 5PO1CA76259] Funding Source: Medline
Since the majority of high-grade breast cancers express reduced levels of BRCA1 mRNA, we investigated the factors regulating BRCA1 transcription. Factors with specific affinity for the previously identified positive regulatory region (PRR) in the BRCA1 promoter were purified from whole-cell extracts. Identified proteins included replication protein A and a series of related factors with affinity for the sense strand of PRR. A subset of the identified factors activated the BRCA1 promoter. Identification of these families of proteins regulating the BRCA1 promoter represents an important step in the comprehension of the mechanisms responsible for breast cancer development.
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