期刊
BIOMETRIKA
卷 90, 期 2, 页码 367-378出版社
BIOMETRIKA TRUST
DOI: 10.1093/biomet/90.2.367
关键词
adaptive design; group-sequential test; likelihood ratio test
Adaptive designs, which,allow the sample size to be modified based on sequentially computed observed treatment differences, have been advocated recently for monitoring clinical trials. Although such methods have a great deal of appeal on the surface, we show that such methods are inefficient and that one can improve uniformly on such adaptive designs using standard group-sequential tests based on the sequentially computed likelihood ratio test statistic.
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