期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 47, 期 6, 页码 2047-2050出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.47.6.2047-2050.2003
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We investigated the molecular basis of the activity of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the etiological agent of Chagas' disease. We found that growth inhibition of T. cruzi epimastigotes induced by this compound was associated with a reduction in the content of the parasite's endogenous sterols due to a specific blockade of their de novo synthesis at the level of squalene synthase.
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