期刊
TRANSPLANTATION PROCEEDINGS
卷 35, 期 4, 页码 1473-1475出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0041-1345(03)00514-1
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Purpose. To describe the results of the treatment of eight liver transplantation (LT) patients subsequently developing large volumes of long-lasting ascites. Patients and Methods. Between August 1996 and February 2003, 405 Us were performed in 375 patients, eight (1.97%) of whom (six men and two women of mean age of 55.4 +/- 5.2 years) subsequently developed massive (> 500 mL/d) and persistent ascites and/or hydrothorax. All patients were HCV positive. The mean age of the liver donors was 66.8 +/- 21.9 years. All LTs were performed by replacement of the recipient retrohepatic vena cava. Results. The eight patients displayed sinusoidal portal hypertension related to biopsyproven recurrence of HCV infection. Mean wedged hepatic venous pressure was 14.9 +/- 5.1 mm Hg and mean portal vein/right atrial pressure gradient (PAPG) was 17.3 +/- 4.8 mm Hg. In two patients, the ascites appeared the day after LT; in the remaining six, ascites and/or hydrothorax appeared after 342.3 +/- 167.7 days. Seven patients with a mean PAPG of 18.4 +/- 3.9 mm Hg and a mean plasma/ascites albumin concentration gradient of 2.8 +/- 0.3 g/L were treated by means of a trans-jugular intrahepatic portosystemic shunt TIPS, and one (with a PAPG of 9 mm Hg and a plasma/ascites albumin concentration gradient of 1.38 g/L) by means of spleen arterial embolisation. After a mean follow-up of 558 147.2 days, the ascites and/or hydrothorax have resolved in five patients (62.5%), one (12.5%) has, stable ascites not requiring paracentesis, and two (25%) have died of multiorgan failure. Conclusion. These data suggest the efficacy of the aggressive treatment of massive and persistent ascites and/or hydrothorax.
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