期刊
JOURNAL OF IMMUNOLOGY
卷 170, 期 11, 页码 5354-5358出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.170.11.5354
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资金
- NIDDK NIH HHS [DK38108] Funding Source: Medline
- PHS HHS [45580, 29564, 41751] Funding Source: Medline
Proteins containing a limited number of N-terminal motifs followed by nucleotide-binding domain and leucine-rich repeat regions are emerging as important regulators for immunity. A search of human genome scaffold databases has identified a large family of known and unknown genes, which we have recently called the CATERPILLER (caspase recruitment domain, transcription enhancer, r(purine)-binding, pyrin, lots of leucine repeats) gene family. This work describes the characterization of a new member, Monarch-1. Monarch-1 has four different splice forms due to the differential splicing of leucine-rich repeat motifs. It is expressed in cells of myeloid-monocytic origin. Affymetrix microarrays and small interfering RNA were used to elucidate the downstream effects of Monarch-1 expression in cells including those of myeloid-monocytic origin. These analyses show that Monarch-1 enhances nonclassical and classical MHC class I expression at the level of the promoter, RNA, and protein expression.
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