期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
卷 65A, 期 3, 页码 402-408出版社
WILEY-LISS
DOI: 10.1002/jbm.a.10518
关键词
calcium-deficient apatite; bone substitute; dynamic compaction; in vivo experiment
Biphasic calcium phosphate (BCP) materials are increasingly used to restore bone loss in surgery. Calcium-deficient apatites (CDA), the precursors of BCP, are closer in structure to biological apatites and can be associated with therapeutic agents to form drug-delivery systems. The purpose of this first hi vivo study of CDA was to evaluate the osteoconductive properties of two composites, consisting of 40-80 mum granules carried by a cellulose-derived polymer, used to fill critical size bone defects in rabbit femoral ends. Animals were sacrificed 2 or 3 weeks after implantation. Histomorphometric analysis of scanning electron microscopy implant surface files was performed using gray level threshold that distinguish between bone or materials (white) and noncalcified tissue (black). Quantitative results for new bone formation showed no significant differences between the composites or the implantation periods. However, nearly all of the CDA disappeared early while supporting more extensive bone colonization than biphasic calcium phosphates implanted in the same conditions. (C) 2003 Wiley Periodicals, Inc. J Biomed Mater Res 64A: 402-408, 2003.
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