期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 46, 期 12, 页码 2279-2282出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm0340602
关键词
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In recent years, the investigation of acetylcholinesterase (AChE) inhibitors has gained further interest, because the involvement of the peripheral site of the enzyme in the beta-amyloid (Abeta) aggregation process has been disclosed. We present here, for the first time, a direct evidence of the Abeta antiaggregating action of an AChE inhibitor (AP2238) purposely designed to bind at both the catalytic and the peripheral sites of the human enzyme.
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