期刊
NEUROSCIENCE LETTERS
卷 343, 期 2, 页码 129-133出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/S0304-3940(03)00174-5
关键词
global ischemia; rat; human neural stem cell; transplantation; intravenous; chimera; migration; differentiation; radial glia; hippocampus
Intraparenchymally transplanted rodent-origin neural and human-origin mesenchymal stem cells migrate and differentiate in neurological diseases. By intravenously injecting human neural stem cells, we showed that transplanted human neural stem cells migrate to the damaged hippocampus, proliferate and differentiate into mature neurons and astrocytes in the adult rat brain with transient forebrain ischemia. We also demonstrated the migratory course of implanted human neural stem cells after intravenous injection. Our findings show that transplanted human neural stem cells differentiate into mature neurons to replace lost neural cells in the adult hippocampus with human-rat neural chimeras. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
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