期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1000, 期 1-2, 页码 477-501出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0021-9673(03)00507-7
关键词
reviews; water analysis; atmospheric pressure ionization; pollutants, polar
Liquid chromatography-mass spectrometry using atmospheric pressure ionization (LC-API-MS) has drastically changed the analytical methods used to detect polar pollutants in water. The present status of application of this technique to organic water constituents is reviewed. The selection of the appropriate LC conditions, whether reversed-phase liquid chromatography, ion-pair chromatography, capillary electrophoresis or ion chromatography, and of the most sensitive ionization mode, electrospray ionization (ESI) or atmospheric pressure chemical ionization (APCI), depends upon the polarity and acidity of the analytes. Strongly acidic compounds such as aromatic sulfonates, sulfonated dyes, haloacedc acids, linear alkylbenzene sulfonates. aliphatic sulfonates and sulfates and complexing agents, weakly acidic compounds such as carboxylates and phenols, neutral compound classes, namely alkylphenol ethoxylates, alcohol ethoxylates and polycyclic aromatic hydrocarbons and the basic toxins, quaternary ammonium compounds and organometallic compounds are considered. The selection of the mass spectrometer depends upon the analytical task: triple-quadrupole mass spectrometers are highly suited for sensitive quantitation and for qualitative analyses, ion traps are especially suited for structure elucidation, whereas time-of-flight mass spectrometers and quadrupole time-of-flight mass spectrometers with their higher mass resolution are ideal for the determination of molecular formulas of unknown compounds and for screening purposes. While large steps have already been made, future efforts with respect to water analysis may be directed at fine-tuning the methodical arsenal for increased sensitivity and selectivity and to extend LC-MS application to transformation products. (C) 2003 Elsevier Science B.V. All rights reserved.
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