期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1000, 期 1-2, 页码 963-984出版社
ELSEVIER
DOI: 10.1016/S0021-9673(03)00435-7
关键词
thin-layer chromatography; reviews; planar chromatography
The purpose of this article is to identify core technologies with the potential to influence the development of thin-layer chromatography over the next decade or so. Core technologies are identified as: (i) methods to provide a constant and optimum mobile phase velocity (forced flow and electroosmotically-driven flow), (ii) video densitometry for recording multidimensional chromatograms, (iii) in situ scanning mass spectrometry, and (iv) bioactivity monitoring for selective detection. In combination with two-dimensional, multiple development and coupled column-layer separation techniques these core technologies could dramatically increase the use of thin-layer chromatography for the characterization of complex mixtures. It is also demonstrated that thin-layer chromatography has strong potential as a surrogate chromatographic model for estimating biopartitioning properties. To convert these opportunities into practice the current state-of-the-art of the core technologies is described and the principle obstacles to progress identified. (C) 2003 Elsevier Science B.V. All rights reserved.
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