期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1000, 期 1-2, 页码 413-436出版社
ELSEVIER
DOI: 10.1016/S0021-9673(03)00506-5
关键词
reviews; instrumentation, LC-MS; liquid chromatography-mass spectrometry; interfaces, LC-MS; ionization techniques; mass analysis; high-throughput screening
In the past 10 years, liquid chromatography-mass spectrometry (LC-MS) has rapidly matured to become a very powerful and useful analytical tool that is widely applied in many areas of chemistry, pharmaceutical sciences and biochemistry. In this paper, recent instrumental developments in LC-MS-related interfacing, ionization and mass analysis are reviewed from the perspective of the application of LC-MS in high-throughput screening of combinatorial libraries and the related high-throughput quantitative bioanalysis in early drug-discovery studies, such as early adsorption, distribution, metabolism and excretion studies. (C) 2003 Elsevier Science B.V. All rights reserved.
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