Organoplatinum(II) complexes as a color biomarker in solid-phase peptide chemistry and screening

A novel organoplatinum(II) biomarker is introduced to facilitate the solid-phase screening of combinatorial libraries for substrates and inhibitors of enzymes and receptors. The robust organoplatinum(II) biomarker can be incorporated, on amine functions, in peptides using standard peptide coupling techniques. The chemistry, stability, and (reversible) coloration process with Kl(3) of the organoplatinum(II) biomarker was investigated.