期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 68, 期 12, 页码 4984-4987出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo034380t
关键词
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A novel enantioselective alkylation of double benzylic substrates with secondary electrophiles is reported. A simple norephedrine-based chiral ligand was synthesized that gives alkylation product in 95% yield and 95% ee. A unique water effect on the enantioselectivity was unveiled. Good to excellent ee values were obtained with a number of double benzylic substrates and secondary electrophiles. This novel reaction has been applied to the synthesis of a promising anticancer agent.
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