期刊
CIRCULATION RESEARCH
卷 92, 期 11, 页码 1182-1192出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/01.RES.0000074908.17214.FD
关键词
cardiac muscle; t-tubules; excitation-contraction coupling; heart failure
The transverse tubules (t-tubules) of mammalian cardiac ventricular myocytes are invaginations of the surface membrane. Recent studies have suggested that the structure and function of the t-tubules are more complex than previously believed; in particular, many of the proteins involved in cellular Ca2+ cycling appear to be concentrated at the t-tubule. Thus, the t-tubules are an important determinant of cardiac cell function, especially as the main site of excitation-contraction coupling, ensuring spatially and temporally synchronous Ca2+ release throughout the cell. Changes in t-tubule structure and protein expression occur during development and in heart failure, so that changes in the t-tubules may contribute to the functional changes observed in these conditions. The purpose of this review is to provide an overview of recent studies of t-tubule structure and function in cardiac myocytes.
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