期刊
JOURNAL OF THE NEUROLOGICAL SCIENCES
卷 210, 期 1-2, 页码 41-45出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0022-510X(03)00013-3
关键词
Guillain-Barre syndrome; acute motor axonal neuropathy; anti-GM1b antibody; anti-GM1 antibody; Campylobacter jejuni; axonal degeneration; molecular mimicry
Anti-GM1 and anti-GM1b antibodies are frequently present in patients with Guillain-Barre syndrome (GBS) and accordingly, the two antibodies often coexist in the same patient. In order to study clinical and laboratory features of anti-GM1b-positive GBS, we analyzed the data of patients with anti-GM1b IgG antibody but no anti-GM1 IgG antibody. Of 86 consecutive patients, 10 had anti-GM1b antibody alone and frequently had acute motor axonal neuropathy (AMAN, 80%) and Campylobacter jejuni infection (60%). Of 10 patients with anti-GM I antibody alone, four had AMAN, and two had C. jejuni infection. These results showed that GM1b Could be a target molecule of autoantibody in the AMAN form of GBS subsequent to C. jejuni infection. (C) 2003 Elsevier Science B.V. All rights reserved.
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