期刊
JOURNAL OF INFECTIOUS DISEASES
卷 187, 期 12, 页码 1967-1971出版社
UNIV CHICAGO PRESS
DOI: 10.1086/375346
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资金
- FIC NIH HHS [2 D 43 TW000010] Funding Source: Medline
- PHS HHS [K24-01637] Funding Source: Medline
During 6 months of treatment, we measured human immunodeficiency virus (HIV)-1 virus loads, CD4 T cell counts, and immune activation markers, in 111 HIV-1-infected patients with active tuberculosis (TB). The median virus load (baseline, 5.58 log(10) copies/mL) significantly increased at 1 month (5.71 log(10) copies/mL), then returned to near-baseline levels at 3 months (5.40 log(10) copies/mL) and at 6 months (5.36 log(10) copies/mL). In contrast, the median CD4 counts increased at I month (186/mm(3)), at 3 months (238/mm(3)), and at 6 months (239/mm(3)). CD4 counts and virus loads did not change during therapy. Expression of CD38 and HLA-DR remained high throughout treatment, whereas plasma levels of interleukin-6 decreased over time.
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