期刊
JOURNAL OF COMPARATIVE NEUROLOGY
卷 461, 期 1, 页码 76-90出版社
WILEY-LISS
DOI: 10.1002/cne.10672
关键词
acetylcholine; nicotinic; muscarinic; cholinergic; presynaptic receptors
资金
- NEI NIH HHS [R01 EY006472-15, P30 EY010608-09, P30 EY010608, R01 EY006472, R01 EY007845, EY10608, EY06472, EY07845] Funding Source: Medline
- NIA NIH HHS [R01 AG005893, AG-05893, F32 AG005893] Funding Source: Medline
- NINDS NIH HHS [NS11323, R01 NS011323] Funding Source: Medline
Starburst amacrine cells in the macaque retina were studied by electron microscopic immunohistochemistry. We found that these amacrine cells make a type of synapse not described previously; they are presynaptic to axon terminals of bipolar cells. We also confirmed that starburst amacrine cells are presynaptic to ganglion cell dendrites and amacrine cell processes. In order to determine the functions of these synapses, we localized acetylcholine receptors using a monoclonal antibody (mAb210) that recognizes human alpha3- and alpha5-containing nicotinic receptors and also antisera against the five known subtypes of muscarinic receptors. The majority of the mAb210-immunoreactive perikarya were amacrine cells and ganglion cells, but a subpopulation of bipolar cells was also labeled. A subset of bipolar cells and a subset of horizontal cells were labeled with antibodies to M3 muscarinic receptors. A subset of amacrine cells, including those that contain cholecystokinin, were labeled with antibodies to M2 receptors. Taken together, these results suggest that acetylcholine can modulate the activity of retinal ganglion cells by multiple pathways. (C) 2003 Wiley-Liss, Inc.
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