期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 197, 期 12, 页码 1677-1687出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20012065
关键词
lymphocyte activation; marginal zone; T cells; transgenic mice; germinal centers
资金
- NIAID NIH HHS [P01 AI035296, AI-39614, R01 AI027998, R37 AI027998, R01 AI059714, AI-27998, AI-35296, R01 AI039614] Funding Source: Medline
- NIGMS NIH HHS [GM-44809, R01 GM044809] Funding Source: Medline
The life history of isotype-switched B cells is unclear, in part, because of an inability to detect rare antigen-specific B cells at early times during the immune response. To address this issue, a small population of B cells carrying targeted antibody transgenes capable of class switching was monitored in immunized mice. After contacting helper T cells, the first switched B cells appeared in follicles rather than in the red pulp, as was expected. Later, some of the switched B cells transiently occupied the red pulp and marginal zone, whereas others persisted in germinal centers (GCs). Antigen-experienced IgM B cells were rarely found in GCs, indicating that these cells switched rapidly after entering GCs or did not persist in this environment.
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