期刊
NEUROSCIENCE LETTERS
卷 344, 期 1, 页码 65-67出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/S0304-3940(03)00416-6
关键词
intervertebral disc; discogenic pain; substance P; isolectin B4; retrograde tracing; fluoro-gold; dorsal root ganglion; immunohistochemistry
The intervertebral discs are innervated by the dorsal root ganglion (DRG) neurons. In the present study, we applied Fluoro-Gold (FG) to the dorsal portion of the L5-L6 intervertebral disc to label DRG neurons retrogradely, and then examined whether FG-labeled neurons were substance P (SP)-immunoreactive or isolectin B4 (1134)-binding. Of the FG-labeled neurons, 44.0% were immunoreactive for SP, whereas only 0.6% were reactive for IB4. The rate of SP-immunoreactive neurons was significantly higher than that of IB4-binding neurons (P < 0.001). suggesting that under physiological conditions the dorsal portion of the lumbar disc is mainly innervated by peptide-containing neurons. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
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