期刊
PROCESS BIOCHEMISTRY
卷 38, 期 11, 页码 1565-1572出版社
ELSEVIER SCI LTD
DOI: 10.1016/S0032-9592(03)00057-8
关键词
neomycin; solid-state fermentation; Streptomyces marinensis NUV-5; optimization; central composite design; response surface methodology
The effect of supplementary nutrients on neomycin production was studied using Streptomyces marinensis NUV-5 in solid-state fermentation. Dextrin, raspberry seed powder, and concentrated mineral medium produced high neomycin yields and were selected for optimization. A full factorial composite experimental design and response surface methodology were used in the design of experiments and in the analysis of results. The maximum productivity of antibiotic under optimum conditions was 17150 mg kg(-1) of wheat rawa. The optimum conditions were dextrin 14.1 g kg(-1) rawa, raspberry seed powder 64.91 g kg(-1) rawa, and mineral salt solution 172.6 ml kg(-1) rawa. This method was efficient; only 20 experiments were necessary to assess these conditions and model adequacy was very satisfactory, as the coefficient of determination was 0.9560. (C) 2003 Published by Elsevier Science Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据