期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 28, 期 7, 页码 349-352出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0968-0004(03)00116-6
关键词
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A novel putative interaction domain - KIND (kinase non-catalytic C-lobe domain) - has been identified as being similar to the C-terminal protein kinase catalytic fold (C lobe). Its presence at the N terminus of signalling proteins and the absence of the active-site residues in the catalytic and activation loops suggest that it folds independently and is likely to be non-catalytic. The occurrence of the novel domain only in metazoa implies that it has evolved from the catalytic protein kinase domain into an interaction domain possibly by keeping the substrate-binding features.
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