期刊
CLINICAL BIOCHEMISTRY
卷 36, 期 5, 页码 359-365出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0009-9120(03)00063-8
关键词
Helicobacter pylori; Cag(A) antigen; lipid profile; Lp(a); atherogenic risk
资金
- Telethon [951] Funding Source: Medline
Objectives: Helicobacter pylori is a controversial risk factor for atherosclerosis. We investigated whether the bacterium persistent inflammation or the expression of the cytotoxin-associated gene A (CagA) may affect serum lipids as well as Lipoprotein(a). Design and methods: Two hundred-eleven healthy volunteers were evaluated for lipids and Lipoprotein(a). Helicobacter pylori was characterized by Urea Breath Test and IgG-anti-CagA. apo(a) Kringle-IV polymorphism was genotyped. Results: Prevalence of the infection was 72%; 43% of subjects expressed CagA reactivity. Infected subjects showed increased levels of cholesterol, LDL-cholesterol, and cholesterol/HDL-cholesterol atherogenic index. Association with the Helicobacter pylori CagA(-) strains persisted after the adjustment for covariates. Significant difference between infected and uninfected subjects was found in Lipoprotein(a) levels. This difference did not arise from the Kringle-IV genotype. Conclusions: The infection per se significantly modified serum lipid and Lipoprotein(a) concentrations. CagA does not seem to be a reliable marker of pathogenicity for the atherogenic complications of H. pylori infection. (C) 2003 The Canadian Society of Clinical Chemists. All rights reserved.
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