期刊
TRAFFIC
卷 4, 期 7, 页码 435-442出版社
WILEY
DOI: 10.1034/j.1600-0854.2003.t01-1-00103.x
关键词
Chlamydomonas; cilia; dynein; flagella; IFT; intraflagellar transport; kinesin
类别
资金
- NIGMS NIH HHS [GM61920] Funding Source: Medline
First discovered in the green alga, Chlamydomonas , intraflagellar transport (IFT) is the bidirectional movement of protein particles along the length of eukaryotic cilia and flagella. Composed of similar to16 different proteins, IFT particles are moved out to the distal tip of the organelle by kinesin-II and are brought back to the cell body by cytoplasmic dynein 1b. Mutant analysis of the IFT motor and particle proteins using diverse organisms has revealed a conserved and essential role for IFT in the assembly and maintenance of cilia and flagella. IFT is thought to mediate this assembly through the delivery of axonemal precursors out to the distal tip of the growing organelle. Consistent with this model, the IFT particle proteins are rich in protein-protein binding motifs, suggesting that the particles may act as scaffolds for the binding of multiple cargoes. With most of the IFT proteins now identified at the level of the gene, this review will briefly examine both the structure and function of the IFT machinery of Chlamydomonas reinhardtii .
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