期刊
MECHANISMS OF DEVELOPMENT
卷 120, 期 7, 页码 747-758出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0925-4773(03)00081-9
关键词
ovo/svb; morphogenesis; actin cytoskeleton; Drosophila
In Drosophila, differentiation of the epidermis results in a stereotyped array of cells with F-actin-based extensions at their apical face. We identified Ovo/Shavenbaby (Svb) as a transcription factor that governs changes in epidermal cell shape. Svb is required for the formation of apical extensions and cells deficient in svb differentiate a smooth surface. In both the embryo and the adult, we show that Svb is necessary and sufficient for the cells to grow extensions and that the tight regulation of ovo/svb activity is critical for motphogenesis to occur correctly. We establish that Svb triggers early F-actin redistribution and is able to initiate the entire process of cytoskeletal remodelling, thereby defining it as a major regulator of epidermal differentiation. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
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