期刊
GENESIS
卷 36, 期 3, 页码 158-161出版社
WILEY-LISS
DOI: 10.1002/gene.10208
关键词
patched; Ptc; conditional knockout; developmental anomalies; cancer; Cre : lox
The patched gene (Ptc) is a member of the hedgehog signaling pathway which plays a central role in the development of many invertebrate and vertebrate tissues. In addition, Ptc and a number of other pathway members are mutated in some common human cancers. Patched is the receptor for the hedgehog ligand and in the mouse ablation of the Ptc gene leads to developmental defects and an embryonic lethal phenotype. Here we describe a conditional Ptc allele in mice which will have utility for the temporospatial ablation of Ptc function. genesis 36:158-161, 2003. (C) 2003 Wiley-Liss, Inc.
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