期刊
JOURNAL OF COMPUTATIONAL NEUROSCIENCE
卷 15, 期 1, 页码 29-41出版社
SPRINGER
DOI: 10.1023/A:1024418701765
关键词
Hermissenda; synaptic facilitation; simulation; model
资金
- NINDS NIH HHS [P01 NS38310] Funding Source: Medline
Pavlovian conditioning in Hermissenda produces a decrease in voltage-dependent (I-K,I-A and I-Ca) and Ca2+-dependent (I-K,I-Ca) currents, and an increase in the action potential (AP) duration in type B-photoreceptors. In addition, synaptic connections between B and A photoreceptors and B photoreceptor and type I interneurons are facilitated. The increase in AP duration, produced by decreasing one or more K+ currents, may account for synaptic facilitation. The present study examined this issue by using a mathematical model of the B-photoreceptor and the neurosimulator SNNAP. In the model, decreasing g(K,A) by 70% increased the duration of the AP in the terminal by 41% and Ca2+ influx by 30%. However, if the decrease in g(K,A) was combined with a decrease in g(Ca), similar to what has been reported experimentally, the Ca2+ influx decreased by 54%. Therefore, the concomitant change in I-Ca counter-acted the broadening-induced increase in Ca2+ influx in the synaptic terminal. This result suggests that a spike-duration independent process must contribute to the synaptic facilitation observed following Pavlovian conditioning.
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