期刊
MEMORIAS DO INSTITUTO OSWALDO CRUZ
卷 98, 期 5, 页码 709-712出版社
FUNDACO OSWALDO CRUZ
DOI: 10.1590/S0074-02762003000500021
关键词
naphthoquinone; Eleutherine bulbosa; fungicide; medicinal plant; Ciadosporium sphaerospermum
The dichloromethane extract prepared from the underground parts of Eleutherine bulbosa (Miller) Urban (Iridaceae) showed strong activity in the direct bioautography assay with the phytopathogenic fungus Cladosporium sphaerospermum. This assay was used to guide the fractionation of this extract and allowed the isolation of four compounds: the new naphthoquinone eleutherinone [8-methoxy-1-methyl-1,3-dihydro-naphtho(2,3-c)furan-4,9-dione] and the known compounds, previously isolated from this species, eleutherin [9-methoxy-1(R),3(S)-dimethyl-3,4-dihydro-1H-benzo(g)isochromene-5,10-dione], isoeleutherin [9-methoxy-1(R),3(R)-dimethyl-3,4-dihydro-1H-benzo(g)isochromene-5,10-dione], and eleutherol [4-hydroxy-5-methoxy-3(R)-methyl-3H-naphtho(2,3-c)furan-1-one]. All quinonoid compounds showed strong antifungal activity in the bioautography assay at 100 mug/spot, while eleutherol was inactive.
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