期刊
MACHINE VISION AND APPLICATIONS
卷 14, 期 3, 页码 145-156出版社
SPRINGER-VERLAG
DOI: 10.1007/s00138-002-0076-z
关键词
karyotyping; analysis of chromosomes; multiresolution images; curvature function; chromosome classification
This paper presents a method to segment, characterise and pair a set of chromosomes in a cell of an eukaryotic organism. This method yields several new features: (i) chromosomes are captured at non-uniform resolution to minimise the problem instance; (ii) segmentation is adaptively conducted by means of a hierarchical structure in a fast way; (iii) the curvature of each chromosome is studied at high resolution by means of attentive steps; (iv) a very short and uncorrelated feature vector is extracted from curvature by analysing its spectral components; and (v) a multistage benchmark classifier is used to pair chromosomes according to shape and banding. The method has been tested with publicly available databases. Results were successfully compared to manual karyotypes.
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