期刊
JOURNAL OF LABORATORY AND CLINICAL MEDICINE
卷 142, 期 1, 页码 35-45出版社
MOSBY-ELSEVIER
DOI: 10.1016/S0022-2143(03)00069-6
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To better understand potentially reversible causes of idiopathic intracranial hypertension (IIH), also known as pseudotumor cerebri, and an apparent association of IIH with polycystic-ovary syndrome (PCOS), we assessed associations of IIH with coagulation disorders and with PCOS in 38 women with well-documented IIH. Fifteen women were found to have PCOS; 14 of them were obese, with a body-mass index (BMI) greater than 30 kg/m(2), and 10 were extremely obese (BMI greater than or equal to 40). Factor VIII concentration was high (> 150%) in 9 of 38 (24%) IIH cases, compared with 0 of 40 healthy adults controls (P-f =.0009). Familial aggregation of high concentrations of factor VIII, associated with thrombophilia, was documented in all 5 of the 9 high-level factor VIII probands' families who were sampled. Activated partial thromboplastin time (APTT) was prolonged (greater than or equal to31.5 seconds) in 10 of 38 (26%) IIH cases, compared with 1 of 32 (3%) controls (P-f =.009) and, in 4 of these cases, was accompanied by the lupus anticoagulant. Plasminogen activator inhibitor activity (PAI-Fx) was high (>21.1 U/ml) in 9 of 38 cases (24%), compared with 1 of 40 controls (3%) (Pf =.006). Lipoprotein A was high (greater than or equal to35 mg/dL) in 13 of 37 cases (35%), compared with 5 of 40 controls (13%) (P-f =.03). IIH cases did not differ (P >.05) from controls for homocysteine, proteins C and S, free S, antithrombin III, ACLAs IgG and IgM, dilute Russell's viper venom time, Factor XI, factor V Leiden G1691A, G20210A prothrombin, C677T MTHFR, plasminogen activator inhibitor 4G/5G, or platelet glycoprotein PLA1A2 mutations. Exogenous estrogens (n = 23), clomiphene (n = 1), or pregnancy (n = 4) accompanied the first appearance of IN in 28 women. PCOS and coagulation disorders, often augmented by exogenous estrogens or pregnancy, are associated with IIH.
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