期刊
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
卷 67, 期 1, 页码 19-26出版社
SPRINGER BASEL AG
DOI: 10.1007/s00005-018-0524-8
关键词
Mesenchymal-epithelial cross-talk; Inflammatory bowel disease; Myofibroblasts; Intestinal stem cells; Stem cell niche
类别
资金
- Jagiellonian University Medical College [K/ZDS/005454]
Epithelial cells are one of the most actively cycling cells in a mammalian organism and therefore are prone to malignant transformation. Already during organogenesis, the connective tissue (mesenchyme) provides instructive signals for the epithelium. In an adult organism, the mesenchyme is believed to provide crucial regulatory signals for the maintenance and regeneration of epithelial cells. Here, we discuss the role of intestinal myofibroblasts, -smooth muscle actin-positive stromal (mesenchymal) cells, as an important regulatory part of the intestinal stem cell niche. Better understanding of the cross-talk between myofibroblasts and the epithelium in the intestine has implications for advances in regenerative medicine, and improved therapeutic strategies for inflammatory bowel disease, intestinal fibrosis and colorectal cancer.
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