期刊
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
卷 1, 期 7, 页码 1575-1579出版社
WILEY
DOI: 10.1046/j.1538-7836.2003.00279.x
关键词
inflammation; insulin resistance syndrome; obesity; PAI-1; vascular risk
Elevated plasma plasminogen activator inhibitor-1 (PAI-1) level is a core feature of insulin-resistance syndrome (IRS). Atherothrombotic complications in IRS are partly attributed to impaired fibrinolysis caused by increased plasma PAI-1 levels. Although the etiology of IRS is far from being explained, the clustering of inflammation, adipose tissue accumulation and insulin resistance suggests an etiopathological link. Proinflammatory cytokines might regulate PAI-1 expression in IRS; however. more studies are needed to confirm this complex mechanism in humans. Furthermore, modifying PAI-1 expression by PAI-1 inhibitors provides a new challenge and may reveal the true role of PAI-1 in atherosclerotic and insulin resistance processes.
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