期刊
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
卷 59, 期 4, 页码 301-307出版社
SPRINGER BASEL AG
DOI: 10.1007/s00005-011-0132-3
关键词
HIF inhibitors; Cancer; Treatment
类别
资金
- Ministry of Science and Higher Education (Poland) [N402 458738]
Hypoxia that originates from disturbed growth of solid tumors initiates a cascade of intracellular events engaging hypoxia-inducible factors, HIF-1 and HIF-2. Overexpression of HIF has been confirmed in solid tumors and was unfortunately accompanied with chemo- and radioresistance observed in many patients. Multiple cellular pathways resulting in HIF activation could be successfully inhibited by use of different kinds of drugs (e.g. topotecan, heat shock protein 90 and mTOR inhibitors, YC-1, pleurotin or 2-methoxyestradiol), which are being subjected into intensive investigation in clinical trials.
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