期刊
MAGNETIC RESONANCE IN CHEMISTRY
卷 41, 期 7, 页码 509-516出版社
JOHN WILEY & SONS LTD
DOI: 10.1002/mrc.1206
关键词
NMR; H-1 NMR; LC-NMR; DI-NMR; FIA-NMR; drug discovery; combinatorial chemistry; quantification
Details of a new flow NMR technique, flow injection analysis NMR (FIA-NMR), are presented for the first time. This method blends some aspects of both liquid chromatography-NMR and direct injection NMR, and complements both. FIA-NMR is shown to be useful as an analytical technique, especially for repetitive analyses, and may also prove useful in the analysis of combinatorial chemistry libraries. The feasibility of FIA-NMR is demonstrated by the quantitative analysis of an over-the-counter pharmaceutical. Copyright (C) 2003 John Wiley Sons, Ltd.
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