Flow injection analysis NMR (FIA-NMR): a novel flow NMR technique that complements LC-NMR and direct injection NMR (DI-NMR)

Details of a new flow NMR technique, flow injection analysis NMR (FIA-NMR), are presented for the first time. This method blends some aspects of both liquid chromatography-NMR and direct injection NMR, and complements both. FIA-NMR is shown to be useful as an analytical technique, especially for repetitive analyses, and may also prove useful in the analysis of combinatorial chemistry libraries. The feasibility of FIA-NMR is demonstrated by the quantitative analysis of an over-the-counter pharmaceutical. Copyright (C) 2003 John Wiley Sons, Ltd.