期刊
GENES & DEVELOPMENT
卷 17, 期 13, 页码 1663-1676出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1101303
关键词
PKC delta; Xenopus; gastrulation; convergent extension; noncanonical Wnt pathway
Protein kinase C (PKC) has been implicated in the Wnt signaling pathway; however, its molecular role is poorly understood. We identified novel genes encoding delta-type PKC in the Xenopus EST databases. Loss of PKCdelta function revealed that it was essential for convergent extension during gastrulation. We then examined the relationship between PKCdelta and the Wnt pathway. PKCdelta was translocated to the plasma membrane in response to Frizzled signaling. In addition, loss of PKCdelta function inhibited the translocation of Dishevelled and the activation of c-Jun N-terminal kinase (INK) by Frizzled. Furthermore, PKCdelta formed a complex with Dishevelled, and the activation of PKCdelta by phorbol ester was sufficient for Dishevelled translocation and INK activation. Thus, PKCdelta plays an essential role in the Wnt/JNK pathway by regulating the localization and activity of Dishevelled.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据