期刊
METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
卷 25, 期 6, 页码 447-452出版社
PROUS SCIENCE, SAU-THOMSON REUTERS
DOI: 10.1358/mf.2003.25.6.769650
关键词
Chinese herbal medicine; D-galactose; glutathione peroxidase; malondialdehyde; superoxide dismutase; total antioxidant status
A mixture of traditional Chinese herbs ('FTDA') was found to improve several oxidation-related biomarkers in D-galactose-induced mimetic aging mice. FTDA consists of seven herbal components: Cuscutae Semen, Schisandrae Fructus, Dioscoreae Rhizoma, Lonicerae Flos, Nelumbinis Semen, Angelica Radix and Poria, and is routinely used for treating mice with D-galactose-induced oxidative damage. Measurements of antioxidant status, including superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), total antioxidant status (TAS) and malondialdehyde (MDA) were made oil blood, brain and liver tissue collected from annuals after 60 days of treatment with D-galactose subcutaneous injections. High-dose, medium-dose and control groups exhibited higher levels of SOD, GSH-Px and TAS in their blood, as well as lower levels of serum MDA activity, compared with the D-galactose group. In the liver, all three experimental and PBS groups demonstrated significant increases in SOD activity and a decrease in MDA activity. The MDA activity decreased in medium-dose, high-dose and PBS groups, while medium-dose and PBS groups demonstrated increased SOD activity computed with that seen in the brain. These results support the efficacy of FTDA in improving the antioxidant status of D-galactose-induced mimetic aging mice. (C) 2003 Prous Science. All rights reserved.
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