期刊
NATURE REVIEWS GENETICS
卷 4, 期 7, 页码 566-572出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg1115
关键词
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Biologists were puzzled by the discovery of left-handed Z-DNA because it seemed unnecessary. Z-DNA was stabilized by the negative supercoiling generated by transcription, which indicated a transient localized conformational change. Few laboratories worked on the biology of Z-DNA. However, the discovery that certain classes of proteins bound to Z-DNA with high affinity and great specificity indicated a biological role. The most recent data show that some of these proteins participate in the pathology of poxviruses.
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