期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 60, 期 7, 页码 1281-1295出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-003-2287-5
关键词
isoaspartate; protein-L-isoaspartyl O-methyltransferase; S-adenosyl-L-methionine; deamidation; protein methylation; peptide bond; protein damage
Formation of beta-linked Asp-Xaa peptide bonds - isoaspartyl (isoAsp) sites - arise in proteins via succinimide-linked deamidation of asparagine or dehydration of aspartate. reactions which represent a major source of spontaneous protein damage under physiological conditions. Accumulation of atypical isoaspartyl sites is minimized in vivo by the activity of protein L-isoaspartyl O-methyltransferase (PIMT), which regenerates a normal peptide bond. Loss of PIMT has harmful consequences, especially in neurons; thus, formation of isoAsp sites and their subsequent correction by PIMT is widely believed to constitute an important pathway of protein damage and repair. Recent evidence is mounting, however, that deamidation and isoaspartate formation may, in some instances, constitute a novel mechanism for intentional modification of protein structure. Herein we describe the mechanism of Asx rearrangement, summarize the evidence that PIMT serves an important repair function, and then focus on emerging evidence that deamidation and isoAsp formation may sometimes have a useful function.
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