Increasing the performance of high-pressure, high-efficiency electrokinetic micropumps using zwitterionic solute additives

A zwitterionic additive is used to improve the performance of electrokinetic micropumps (EK pumps), which use voltage applied across a porous matrix to generate electroosmotic pressure and flow in microfluidic systems. Modeling of EK pump systems predicts that the additive, trimethylammoniopropane sulfonate (TMAPS), will result in up to a 3.3-fold increase in pumping efficiency and up to a 2.5-fold increase in the generated pressure. These predictive relations compare well with experimental results for flow, pressure and efficiency. With these improvements, pressures up to 156 kPa/V (22 psi/V) and efficiency up to 5.6% are demonstrated. Similar improvements can be expected from a wide range of zwitterionic species that exhibit large dipole moments and positive linear dielectric increments. These improvements lead to a reduction in voltage and power requirements and will facilitate miniaturization of micro-total-analysis systems (muTAS) and microfluidically driven actuators. Published by Elsevier Science B.V.