期刊
JOURNAL OF MASS SPECTROMETRY
卷 38, 期 7, 页码 699-708出版社
JOHN WILEY & SONS LTD
DOI: 10.1002/jms.505
关键词
sample preparation; MALDI-MS; tissue analysis; imaging MS; proteins
Practical guidelines for the preparation of tissue sections for direct analysis by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry are presented. Techniques for proper sample handling including tissue storage, sectioning and mounting are described. Emphasis is placed on optimizing matrix parameters such as the type of matrix molecule used, matrix concentration, and solvent composition. Several different techniques for matrix application are illustrated. Optimal instrument parameters and the necessity for advanced data analysis approaches with regards to direct tissue analysis are also discussed. Copyright (C) 2003 John Wiley Sons, Ltd.
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